Grants and Contributions

Integran proposes to develop a unique, hybrid coating with durable-hydrophobic, antiviral and antimicrobial properties. The proposed coating will possess easy-to-clean properties while rapidly and continuously deactivating viruses and killing harmful bacteria and fungi on contact. The proposed coating has the ability to reduce fomite transmission (indirect contact transmission) of viruses (including COVID-19), bacteria and fungi, which can result in significant social, health, and economic benefits.

The proposed coating will continuously kill 99.9% of bacteria and deactivate viruses. The coating will possess the ideal properties to ensure that surfaces remain cleaner and less contaminated between cleanings, while also reducing the time and effort needed to clean, sanitize, and decontaminate surfaces. The proposed coating will be compatible with most surfaces, including metals, plastics, composites, glass, ceramic and wood. It can be applied in-situ onto existing surfaces, without the need for expensive renovations or replacements.

The proposed coating seeks to combine two of Integran's proven technologies: (i) durable-hydrophobic polymer coatings, and (ii) nanostructured antiviral and antimicrobial metals.

EnvisionSQ has developed an innovative disinfectant for application on virtually any surface, either in-situ or off-site, to help prevent spread of bacteria and viruses. This product is currently being submitted to Health Canada for approval. GermStopSQ is designed as a high-performing antimicrobial and antiviral disinfectant that works around the clock. The liquid formulation kills on contact and when dry, creates a clear, selfsanitizing coating material that ruptures the target organism’s protective outer covering. Independent tests show the GermStopSQ coating is more than 99.9999% effective at killing a broad range of microbes and 99.993% effective at killing coronavirus 229E, a recognized proxy for SARS-CoV-2, the virus that causes COVID-19. Thanks to its nanoengineered properties and unique polymer structure, GermStopSQ bonds to both hard and soft surfaces. It can be applied using a variety of delivery modes — spraying, rolling or wiping — depending on the type of surface. Once applied, it creates an invisible and durable film network structure. Its active ingredient is designed to keep surfaces disinfected for days, while a special photocatalytic ingredient provides additional disinfection every time it’s exposed to light. With this project, Envision SQ aims to optimize the GermStopSQ formulation for use in enclosed spaces and around sensitive equipment.

The proposes using the Hydroxyl Radical Sterilization Method to clean sensitive equipment and workspaces. The process includes two steps. First, the cold vapour of hydrogen peroxide generated and allowed to penetrate porous surfaces, cavities, vents in equipment and other complicated and hard to reach surfaces in rooms, vessels, aircraft and vehicles. Due to a relatively high boiling point (150.2 °C), hydrogen peroxide tends to concentrate on solid surfaces. When the required concentration of hydrogen peroxide in the air is achieved, it is mixed with a limited and controllable amount of ozone added to the air in the treated space, and this is the second step. Ozone reacts with hydrogen peroxide by a reaction known as the peroxone oxidation that generates shortliving hydroxy radicals (OH·). Hydroxy radicals have very high disinfecting activity, much more effective than ozone or hydrogen peroxide alone. The final products of ozone and hydrogen peroxide reaction are harmless water vapour and oxygen. This means that as soon as ozone is sufficiently well mixed with the hydrogen peroxide in the treated room, no hydrogen peroxide nor ozone will remain in the air or on surfaces. The disinfected space and equipment would be safe to use immediately without ventilation.

The overall goal of this project is to advance the clinical development of Poly-ICLC (Hiltonol®), a broad-spectrum antiviral drug candidate, as an innovative solution to strengthen medical preparedness against viral threats.

Funding will support research and development to identify solutions to National Defence’s Rapid Response: Real-time Insights for Pandemic Decision Making Challenge.
Defence Research and Development Canada (DRDC) in collaboration with Canada’s defence, security and public safety communities is looking for innovative epidemiological and healthcare solutions involving data gathering and data analytics technologies to support the early detection and community-based surveillance of outbreaks of contagious diseases. The goal is to provide actionable insights and to permit rapid decision-making with respect to the full emergency preparedness spectrum.

Funding will support research and development to identify solutions to National Defence’s Rapid Response: Real-time Insights for Pandemic Decision Making Challenge.
Defence Research and Development Canada (DRDC) in collaboration with Canada’s defence, security and public safety communities is looking for innovative epidemiological and healthcare solutions involving data gathering and data analytics technologies to support the early detection and community-based surveillance of outbreaks of contagious diseases. The goal is to provide actionable insights and to permit rapid decision-making with respect to the full emergency preparedness spectrum.

Funding will support research and development to identify solutions to National Defence’s Super sanitize: Cleaning sensitive equipment and workspaces Challenge. Defence Research and Development Canada (DRDC) in collaboration with Canada’s defence, security and public safety communities are looking for viable and effective processes and methods for safely and rapidly decontaminating enclosed work environments (e.g., buildings and modes of transportation) containing sensitive equipment.

Funding will support research and development to identify solutions to National Defence’s Scrubbing your scrubs: Finding ways to re-use COVID-19 protective gear Challenge. Defence Research and Development Canada (DRDC) in collaboration with Canada’s defence, security and public safety communities is looking for innovative material and design solutions, as well as rapid and effective decontamination strategies and solutions, for Personal Protective Equipment (PPE), operational clothing and equipment for personnel responding to events involving biological hazards.

Funding will support research and development to identify solutions to National Defence’s Rapid Response: Real-time Insights for Pandemic Decision Making Challenge.
Defence Research and Development Canada (DRDC) in collaboration with Canada’s defence, security and public safety communities is looking for innovative epidemiological and healthcare solutions involving data gathering and data analytics technologies to support the early detection and community-based surveillance of outbreaks of contagious diseases. The goal is to provide actionable insights and to permit rapid decision-making with respect to the full emergency preparedness spectrum.

Funding will support research and development to identify solutions to National Defence’s Super sanitize: Cleaning sensitive equipment and workspaces Challenge. Defence Research and Development Canada (DRDC) in collaboration with Canada’s defence, security and public safety communities are looking for viable and effective processes and methods for safely and rapidly decontaminating enclosed work environments (e.g., buildings and modes of transportation) containing sensitive equipment.