Grants and Contributions

The purpose of this CanExport SMEs agreement is to support small- and medium-sized enterprises (SMEs) for activities related to export market development that are part of an export business case for a specific target market, particularly where activities are targeting departmental priority markets and sectors.

The purpose of this CanExport SMEs agreement is to support small- and medium-sized enterprises (SMEs) for activities related to export market development that are part of an export business case for a specific target market, particularly where activities are targeting departmental priority markets and sectors.

The purpose of this CanExport SMEs agreement is to support small- and medium-sized enterprises (SMEs) for activities related to export market development that are part of an export business case for a specific target market, particularly where activities are targeting departmental priority markets and sectors.

The purpose of this CanExport SMEs agreement is to support small- and medium-sized enterprises (SMEs) for activities related to export market development that are part of an export business case for a specific target market, particularly where activities are targeting departmental priority markets and sectors.

The purpose of this CanExport SMEs agreement is to support small- and medium-sized enterprises (SMEs) for activities related to export market development that are part of an export business case for a specific target market, particularly where activities are targeting departmental priority markets and sectors.

The purpose of this CanExport SMEs agreement is to support small- and medium-sized enterprises (SMEs) for activities related to export market development that are part of an export business case for a specific target market, particularly where activities are targeting departmental priority markets and sectors.

The current project aims at obtaining relevant data to select the targeted population and clinical biomarkers for the long-term monitoring of efficacy of LPLD gene therapy to support Phase I/II clinical trial design to be proposed to Health Canada at a pre-CTA meeting Definition and validation of the study population and of the main inclusion and exclusion criteria will be performed using data obtained from discussions with Canadian/international experts and from the documentation of the natural history of LPL deficiency, including epigenetic, gene expression and sequencing analyses. The natural history of LPL deficiency, including a panel of critical biomarkers, will become a ‘baseline’ against which to benchmark long-term efficacy of LPLD gene therapy. The analysis and selection of clinical biomarkers will leverage the ongoing research program on the natural history of severe hypertriglyceridemia (SMASH: Systems and Molecular Approaches of Severe Hyperlipidemias) (Table 1). In parallel, the same panel of biomarkers will be monitored in preclinical long-term safety and efficacy study of the lead LPLD gene therapy construct in LPL-/- transgenic mice conducted by UBC. This will provide pre-clinical baseline of potential effect of gene therapy treatment on selected biomarkers representative of the ‘natural’ history of disease in humans. ( Figure 1). Studies above will allow to identify safety and efficacy assessment criteria that will be used in the clinical trial, including the definition of the primary and secondary objectives, as well as to identify all potential concurrent and companion treatments. Finally, socioeconomic study of chylomicronemia and pharmacoeconomic analyses will be performed to position this new gene therapy in relation to the competitive environment and the burden of LPL deficiency

The design, simulation and optimization of Aluminum-air Galvanic Generator power density to support higher power applications.

Through the application of national and local priorities, the CSJ program seeks to provide youth, particularly those who face barriers to employment with access to work opportunities. Funded employers must demonstrate that they are providing quality work experiences for youth that provide opportunities to develop and improve their skills.

The objectives of the program are to:.•Support greater influence and control over Indigenous ELCC programs and services by Indigenous peoples;.•Improve quality and accessibility of Indigenous ELCC with an emphasis on cultural and language content;.•Support a more holistic and integrated system of quality ELCC services for Indigenous peoples; and.•Adapt and improve existing federal programs to be more flexible, adaptable and horizontal across federal departments as a first step prior to transferring control..