Grants and Contributions

Through the application of national and local priorities, the CSJ program seeks to provide youth, particularly those who face barriers to employment with access to work opportunities. Funded employers must demonstrate that they are providing quality work experiences for youth that provide opportunities to develop and improve their skills.

Through the application of national and local priorities, the CSJ program seeks to provide youth, particularly those who face barriers to employment with access to work opportunities. Funded employers must demonstrate that they are providing quality work experiences for youth that provide opportunities to develop and improve their skills.

The Project will accelerate the rate at which the NRC’s Lipoprotein lipase deficiency (LPLD) AAV-based gene therapy technology is GMP manufactured and readied for testing in the clinic, by formally combining the efforts, experience and expertise of the National Research Council and the Biotherapeutics Manufacturing Centre- Virus Manufacturing Facility (BMC-VMF) at the Ottawa Hospital Research Institute (OHRI). The project will result in the finalization of upstream and downstream process parameters leading to the execution of a non-GMP run of the complete, finalized process.

To address systemic racism and discrimination in Canada’s health systems by striving to ensure high quality health services are efficient and accessible, and by reducing health inequalities.

This project will engage with Champlain Integrated Health Network, The Ottawa Hospital, Ottawa Public Health, University of Ottawa, and Algonquin College of Nursing to develop their capacity for serving transgender patients.

Through the application of national and local priorities, the CSJ program seeks to provide youth, particularly those who face barriers to employment with access to work opportunities. Funded employers must demonstrate that they are providing quality work experiences for youth that provide opportunities to develop and improve their skills.

Through the application of national and local priorities, the CSJ program seeks to provide youth, particularly those who face barriers to employment with access to work opportunities. Funded employers must demonstrate that they are providing quality work experiences for youth that provide opportunities to develop and improve their skills.

Through the application of national and local priorities, the CSJ program seeks to provide youth, particularly those who face barriers to employment with access to work opportunities. Funded employers must demonstrate that they are providing quality work experiences for youth that provide opportunities to develop and improve their skills.

Researchers will collect publicly available skeletal muscle-relevant single-cell data and in-house cell data from the Ottawa Hospital Research Institute, as well as from the NRC’s Disruptive Technology Solutions for Cell and Gene Therapy Program.

The SARs-CoV-2 coronavirus enters cells by binding to its plasma membrane receptor, angiotensin-converting enzyme 2 (ACE2). ACE2 is a member of the renin-angiotensin system that degrades the vasoconstrictor and pro-inflammatory peptide angiotensin II (Ang II) to its vasodilator, anti-inflammatory product Ang-(1-7).
This Project involves pre-clinical studies of ACE2-Fc variants with potential therapeutic properties against COVID-19. The compounds will be developed to bind and neutralize the SARs-CoV-2 virus, and to exert intrinsic ACE2 activity, thereby reducing detrimental effects of Ang II.
Comprehensive testing of ACE2 enzymatic activity for the designed ACE2-Fc variants arising from this collaboration will be performed. Enzymatic activity testing will be done at three levels:
1. Cell-free assays to test ACE2 enzymatic activity.
2. Cell-based assays using kidney proximal tubular cells.
3. In vivo studies, to determine the effects of lead compounds on blood pressure, kidney injury, and plasma/tissue ACE2 activity in mice with Ang II-mediated hypertension.