Title:
UNDERSTANDING RELATIVE CONTRIBUTIONS OF FLUID FLOW AND MECHANICAL STRAIN TO BONE ADAPTATION IN ALTERED GRAVITY.
Agreement Number:
19HLSRM04
Agreement Value:
$150,000.00
Agreement Date:
Mar 19, 2020 - Mar 31, 2022
Description:
UNDERSTANDING RELATIVE CONTRIBUTIONS OF FLUID FLOW AND MECHANICAL STRAIN TO BONE ADAPTATION IN ALTERED GRAVITY.
Bone loss in astronauts is a major challenge for long-duration space exploration. In weightlessness, muscles are used less often, thus providing less stimulation of bone. Microgravity also induces fluid shift from the lower body towards the head, the role of which in bone loss is unclear. We aim to develop imaging, computational and pharmacological tools to examine contributions of fluid flow and mechanical strain to bone adaptation to mechanical environment using mouse models of mechanical loading and immobilization-induced unloading. Understanding the links between microgravity and bone adaptation will help to prevent bone loss in long-duration human space flights.
Organization:
Canadian Space Agency
Expected Results:
The Research component of the program provides financial support to organizations to conduct space related research and development in priority areas. It will support targeted knowledge development and innovation to sustain and enhance the Canadian capacity to use space to address national needs and priorities in the future.
Location:
Montreal, Quebec, CA H3A 2T5
Reference Number:
003-2019-2020-Q4-04371
Report Type:
Grants and Contributions
Additional Information:
The amount allocated covers more than one fiscal year.
Late Disclosure:
Expected quarter 4 2020-2021
Disclosed quarter 3 2021-2022
Recipient's Legal Name:
Université McGill
Program:
Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Program Purpose:
This program supports knowledge development and innovation in the CSA's priority areas while increasing the awareness and participation of Canadians in space-related disciplines and activities.
The Research Component aims to support the development of science and technology; foster the continual development of a critical mass of researchers and highly qualified people in Canada; and support information gathering and space-related studies and research pertaining to Canadian Space Agency priorities.