Grants and Contributions:

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Agreement Number:
-
Agreement Value:
$150,000.00
Agreement Date:
Mar 19, 2020 -
Description:
UNDERSTANDING RELATIVE CONTRIBUTIONS OF FLUID FLOW AND MECHANICAL STRAIN TO BONE ADAPTATION IN ALTERED GRAVITY. Bone loss in astronauts is a major challenge for long-duration space exploration. In weightlessness, muscles are used less often, thus providing less stimulation of bone. Microgravity also induces fluid shift from the lower body towards the head, the role of which in bone loss is unclear. We aim to develop imaging, computational and pharmacological tools to examine contributions of fluid flow and mechanical strain to bone adaptation to mechanical environment using mouse models of mechanical loading and immobilization-induced unloading. Understanding the links between microgravity and bone adaptation will help to prevent bone loss in long-duration human space flights.
Organization:
Canadian Space Agency
Location:
Montreal, Quebec, CA
Reference Number:
003-2019-2020-Q4-04371
Agreement Type:
Grant
Report Type:
Grants and Contributions
Additional Information:

The amount allocated covers more than one fiscal year.
Late Disclosure:
Expected quarter 4 2020-2021
Disclosed quarter 3 2021-2022

Recipient's Legal Name:
Université McGill