Title:
Role of circadian rhythms in mechanical unloading-related bone loss
Agreement Value:
$150,000.00
Agreement Date:
Mar 29, 2022 - Mar 31, 2024
Description:
Bone loss in astronauts is a major challenge for long-duration space exploration. In weightlessness, muscles are used less often, thus providing less stimulation of bone. In addition, astronauts often have disrupted circadian rhythms. It is known that night and rotating shift workers display an increased incidence of bone fractures. Molecular mechanisms underlying microgravity-induced bone loss are still unclear. This research aims to determine how circadian rhythms contribute to mechanical unloading-related bone loss using mouse models. Understanding the links between circadian rhythms, microgravity and bone adaptation will help to prevent bone loss in long-duration human space flights.
Organization:
Canadian Space Agency
Expected Results:
The Research component of the program provides financial support to organizations to conduct space related research and development in priority areas. It will support targeted knowledge development and innovation to sustain and enhance the Canadian capacity to use space to address national needs and priorities in the future.
Location:
Montreal, Quebec, CA H3A 0G4
Reference Number:
003-2021-2022-Q4-00065
Report Type:
Grants and Contributions
Recipient's Legal Name:
The Royal Institution for the Advancement of Learning/ McGill University
Program:
Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Program Purpose:
This program supports knowledge development and innovation in the CSA's priority areas while increasing the awareness and participation of Canadians in space-related disciplines and activities.
The Research Component aims to support the development of science and technology; foster the continual development of a critical mass of researchers and highly qualified people in Canada; and support information gathering and space-related studies and research pertaining to Canadian Space Agency priorities.