Title:
Harnessing hibernation - evaluating the translational potential of hibernation-related mechanisms of muscle atrophy resistance
Agreement Value:
$149,040.00
Agreement Date:
Mar 29, 2022 - Mar 31, 2024
Description:
This project aims to translate a hibernation-related mechanism of muscle atrophy resistance to astronauts. The microgravity conditions of space invariably lead to profound loss of skeletal and cardiac muscle mass and performance, a phenomenon called spaceflight-induced disuse atrophy. However, hibernating mammals are remarkably resistant to muscle atrophy, and the team has recently identified a gut microbiome-based process that facilitates this resistance by building muscle protein. Here, the team uses proteomics techniques to determine which muscle proteins this process helps build and whether they will counter spaceflight-induced atrophy. The ultimate goal is to create a hibernation-like probiotic to facilitate atrophy resistance in astronauts.
Organization:
Canadian Space Agency
Expected Results:
The Research component of the program provides financial support to organizations to conduct space related research
and development in priority areas. It will support targeted knowledge development and innovation to sustain and enhance the Canadian capacity to use space to address national needs and priorities in the future.
Location:
Montreal, Quebec, CA H3C 3J7
Reference Number:
003-2021-2022-Q4-00068
Report Type:
Grants and Contributions
Recipient's Legal Name:
Université de Montréal
Program:
Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Program Purpose:
This program supports knowledge development and innovation in the CSA's priority areas while increasing the awareness and participation of Canadians in space-related disciplines and activities.
The Research Component aims to support the development of science and technology; foster the continual development of a critical mass of researchers and highly qualified people in Canada; and support information gathering and space-related studies and research pertaining to Canadian Space Agency priorities.