Title:
Global Changes in mRNA Translation Underlying the Unique Mechanisms of Skeletal Muscle Atrophy on Earth and in Space
Agreement Number:
23HLSRM03
Agreement Value:
$150,000.00
Agreement Date:
Sep 26, 2023 - Sep 30, 2025
Description:
Muscle wasting occurs in consequence to pathological conditions, including aging (sarcopenia). In space, healthy astronauts experience severe wasting of the anti-gravity muscles, the muscles that are normally engaged on Earth to maintain posture. Adjunct therapies are required to mitigate the risk of muscle wasting to enable human exploration of space. In this proposal, the research team use genetic tools in the mouse to reveal how protein synthesis, a major determinant of muscle mass, is remodeled in aging mice. Understanding how protein synthesis is remodeled under conditions of muscle wasting on Earth and in space is the first step towards identifying drug targets.
Organization:
Canadian Space Agency
Expected Results:
The Research component of the program provides financial support to organizations to conduct space related research and development in priority areas. It will support targeted knowledge development and innovation to sustain and enhance the Canadian capacity to use space to address national needs and priorities in the future.
Location:
Montreal, Quebec, CA H3T 1E2
Reference Number:
003-2023-2024-Q2-00006
Report Type:
Grants and Contributions
Recipient Type:
Not-for-profit organization or charity
Recipient's Legal Name:
The Sir Mortimer B. Davis-Jewish general Hospital
Program:
Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Program Purpose:
This program supports knowledge development and innovation in the CSA's priority areas while increasing the awareness and participation of Canadians in space-related disciplines and activities.
The Research Component aims to support the development of science and technology; foster the continual development of a critical mass of researchers and highly qualified people in Canada; and support information gathering and space-related studies and research pertaining to Canadian Space Agency priorities.