Title:
Mechanogenomic suppression of microgravity induced chondrocyte hypertrophy in bioengineered human cartilage
Agreement Number:
23HLSRM07
Agreement Value:
$149,442.40
Agreement Date:
Sep 26, 2023 - Sep 30, 2024
Description:
Space’s low gravity leads to bone and muscle loss which can compromise astronauts’ missions. Previous work showed that the knee cartilage of mice breakdown after a period in space’s low gravity. But little is known about the effect of low gravity on human cartilage. The research team will use human stem cells from adult females and males to make cartilage to study the effect of low gravity on cartilage. They will use an instrument designed by NASA to replicate low gravity. They hope their work will shed new light into osteoarthritis, a common disease in Canadians with cartilage breakdown at its core.
Organization:
Canadian Space Agency
Expected Results:
The Research component of the program provides financial support to organizations to conduct space related research and development in priority areas. It will support targeted knowledge development and innovation to sustain and enhance the Canadian capacity to use space to address national needs and priorities in the future.
Location:
Edmonton, Alberta, CA T5J 4P6
Reference Number:
003-2023-2024-Q2-00012
Report Type:
Grants and Contributions
Recipient's Legal Name:
The Governors of the University of Alberta
Program:
Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Program Purpose:
This program supports knowledge development and innovation in the CSA's priority areas while increasing the awareness and participation of Canadians in space-related disciplines and activities.
The Research Component aims to support the development of science and technology; foster the continual development of a critical mass of researchers and highly qualified people in Canada; and support information gathering and space-related studies and research pertaining to Canadian Space Agency priorities.