Title:
Circadian Regulation of Cardiometabolic Function in Space Flight
Agreement Number:
23HLSRM10
Agreement Value:
$150,000.00
Agreement Date:
Sep 29, 2023 - Sep 30, 2025
Description:
It is well-recognized that astronauts experience profound physiological changes that adversely affect the heart owing in part to the effects of changes in the normal circadian light/dark cycle. Furthermore, new compelling data from the research group suggests that accumulation of damaged organelles resulting from impaired cellular quality control processes is an underlying defect contributing to cardiac cell-death and dysfunction following circadian disruption. The relationship between circadian disruption and heart health during spaceflight is not well-studied. Hence, the research team proposes to delineate how circadian disruption influences autophagy, cell-viability and cardiac dysfunction in females versus males in response to altered light/dark cycle during spaceflight.
Organization:
Canadian Space Agency
Expected Results:
The Research component of the program provides financial support to organizations to conduct space related research and development in priority areas. It will support targeted knowledge development and innovation to sustain and enhance the Canadian capacity to use space to address national needs and priorities in the future.
Location:
Winnipeg, Manitoba, CA R3T 2N2
Reference Number:
003-2023-2024-Q2-00014
Report Type:
Grants and Contributions
Recipient's Legal Name:
University of Manitoba
Program:
Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Program Purpose:
This program supports knowledge development and innovation in the CSA's priority areas while increasing the awareness and participation of Canadians in space-related disciplines and activities.
The Research Component aims to support the development of science and technology; foster the continual development of a critical mass of researchers and highly qualified people in Canada; and support information gathering and space-related studies and research pertaining to Canadian Space Agency priorities.