Title:
Machine-learning algorithms for integrating HDT bed rest data and measuring the deconditioning of physiological systems
Agreement Number:
25HLSDM2
Agreement Value:
$75,000.00
Agreement Date:
Jul 17, 2025 - Jul 15, 2026
Description:
During spaceflight, astronauts experience deconditioning; the simultaneous reduction of the functional capacity of multiple body systems leading to weakness and inability to perform activities. Impairments span multiple systems from cardiovascular, musculoskeletal, to immunity all contributing to deconditioning. The scarcity of astronauts’ biological samples combined with technical challenges in space hampers our ability to monitor how the human body copes with space hazards. However, head-down tilt (HDT) bed rest studies represent an Earth-based analogue to microgravity and an opportunity to decipher the molecular mechanisms leading to deconditioning. The research team secured access to European Space Agency (ESA) data collected for the monitoring of participants. We will apply machine-learning algorithms to integrated ESA data and gene expression data collected from the same participants by our Team. Results will reveal predictor and physiological responses for early detection of deconditioning and for the design of interventions to prevent the negative effects of microgravity.
Organization:
Canadian Space Agency
Expected Results:
The Research component of the program provides financial support to organizations to conduct space related research and development in priority areas. It will support targeted knowledge development and innovation to sustain and enhance the Canadian capacity to use space to address national needs and priorities in the future.
Location:
Ottawa, Ontario, CA K1N 6N5
Reference Number:
003-2025-2026-Q2-00078
Report Type:
Grants and Contributions
Recipient's Legal Name:
University of Ottawa
Program:
Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Program Purpose:
This program supports knowledge development and innovation in the CSA's priority areas while increasing the awareness and participation of Canadians in space-related disciplines and activities.
The Research Component aims to support the development of science and technology; foster the continual development of a critical mass of researchers and highly qualified people in Canada; and support information gathering and space-related studies and research pertaining to Canadian Space Agency priorities