Title:
Understanding the molecular and functional heterogeneity of human meniscus fibrochondrocytes and microtissue models under simulated microgravity and
hypergravity
Agreement Number:
25HLSRM5
Agreement Value:
$179,010.70
Agreement Date:
Jul 18, 2025 - Sep 15, 2027
Description:
The pair of menisci in each knee joint protects the cartilage of the joint from excessive stress and enables humans to walk or run with stable knees. However, the meniscus is prone to traumatic tears, especially during sports-related activities, with very little ability to repair itself and presenting a major risk for developing knee osteoarthritis. Recent work from the research team shows that the cells making up the meniscus are diverse. Some cells exhibit features that can repair the meniscus, some display osteoarthritis-like response to space’s low gravity and others show superior ability to make the proteins that support meniscus’ mechanical function in the knee. The research team will study the diverse population of human meniscus cells after exposure to low and high gravity conditions of spaceflight missions using a specialized machine to replicate the gravity conditions of spaceflight missions. They hope their work will shed light on meniscus repair and osteoarthritis.
Organization:
Canadian Space Agency
Expected Results:
The Research component of the program provides financial support to organizations to conduct space related research and development in priority areas. It will support targeted knowledge development and innovation to sustain and enhance the Canadian capacity to use space to address national needs and priorities in the future.
Location:
Edmonton, Alberta, CA J3Y 8Y9
Reference Number:
003-2025-2026-Q2-00088
Report Type:
Grants and Contributions
Recipient's Legal Name:
The Governors of the University of Alberta
Program:
Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Program Purpose:
This program supports knowledge development and innovation in the CSA's priority areas while increasing the awareness and participation of Canadians in space-related disciplines and activities.
The Research Component aims to support the development of science and technology; foster the continual development of a critical mass of researchers and highly qualified people in Canada; and support information gathering and space-related studies and research pertaining to Canadian Space Agency priorities.