Title:
Targeting the RNA-binding protein Staufen1 with FDA-approved drugs to prevent skeletal muscle atrophy
Agreement Number:
25HLSRM7
Agreement Value:
$180,000.00
Agreement Date:
Jul 25, 2025 - Jul 15, 2027
Description:
Muscle atrophy is a condition characterized by the shrinking and weakening of muscles impacting everyday activities. It can occur during extended periods in space due to reduced gravity, as well as in various conditions on Earth, including inactivity, aging, injuries, and diseases. In previous research, the research team identified a protein called Staufen1 that plays a key role in the early stages of muscle atrophy across various conditions, including ground-based human and mouse models of microgravity. Their current research aims to determine if muscle atrophy can be reduced or prevented by modulating Staufen1 levels. In addition, they aim to identify FDA-approved drugs targeting Staufen1. The results of this study have the potential to accelerate the development of new treatments and countermeasures to effectively combat muscle atrophy in diverse conditions.
Organization:
Canadian Space Agency
Expected Results:
The Research component of the program provides financial support to organizations to conduct space related research and development in priority areas. It will support targeted knowledge development and innovation to sustain and enhance the Canadian capacity to use space to address national needs and priorities in the future.
Location:
Ottawa, Ontario, CA K1N 6N5
Reference Number:
003-2025-2026-Q2-00089
Report Type:
Grants and Contributions
Recipient's Legal Name:
University of Ottawa
Program:
Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Program Purpose:
This program supports knowledge development and innovation in the CSA's priority areas while increasing the awareness and participation of Canadians in space-related disciplines and activities.
The Research Component aims to support the development of science and technology; foster the continual development of a critical mass of researchers and highly qualified people in Canada; and support information gathering and space-related studies and research pertaining to Canadian Space Agency priorities.