Title:
The pathophysiology, risk, and clinical presentation of Venous Thromboembolisms (VTE) during dry immersion and bed rest
Agreement Number:
25HLSHANA7
Agreement Value:
$149,568.00
Agreement Date:
Jul 31, 2025 - Jul 15, 2028
Description:
Recent findings suggest that the venous thromboembolisms (VTE) may occur during spaceflight. Jugular vein thrombosis is rarely reported on Earth, but is associated with relatively poor outcomes. Therefore, there is a need to evaluate the upper body venous system, and the effects of microgravity on venous blood flow, blood viscosity, vessel distension, and inflammation. It is also necessary to provide a better description of the molecular mechanisms by assessing how blood clotting genes are differentially expressed under microgravity. To this end, the proposed research will 1) identify jugular vein status and coagulation changes in spaceflight analogue of dry immersion and bed rest by analysis of blood samples, and 2) investigate the molecular mechanisms that underlie the risk of VTEs by assessing the genes associated with coagulation. The outcome of this project would be a better understanding of the potential underlying mechanisms of VTEs in spaceflight.
Organization:
Canadian Space Agency
Expected Results:
The Research component of the program provides financial support to organizations to conduct space related research and development in priority areas. It will support targeted knowledge development and innovation to sustain and enhance the Canadian capacity to use space to address national needs and priorities in the future.
Location:
Burnaby, British Columbia, CA V5A 1S6
Reference Number:
003-2025-2026-Q2-00095
Report Type:
Grants and Contributions
Recipient's Legal Name:
Simon Fraser University
Program:
Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Program Purpose:
This program supports knowledge development and innovation in the CSA's priority areas while increasing the awareness and participation of Canadians in space-related disciplines and activities.
The Research Component aims to support the development of science and technology; foster the continual development of a critical mass of researchers and highly qualified people in Canada; and support information gathering and space-related studies and research pertaining to Canadian Space Agency priorities.