Title:
The unloaded body; blood indicators of deconditioning
Agreement Value:
$100,000.00
Agreement Date:
Mar 23, 2020 - Sep 30, 2024
Description:
This projects aims to identify blood indicators for deconditioning (a state of extreme weakness) from available blood samples. Astronauts experience deconditioning when travelling between gravity environments. Similarly, bedridden patients may develop deconditioning requiring rehabilitation treatment in the hospital. The effect of microgravity on physiological systems is unclear and there is a lack of tools for early detection of deconditioning and for testing countermeasures designed at mitigating the negative effects on health. Early detection of deconditioning in microgravity through a blood molecular signature enables the early assessment of immune functions and the prevention of infection with available medication.
Our previous scientific participation in bedrest studies, an on-Earth model of microgravity, and collected blood samples from participants, provides an opportunity to complement our ongoing gene expression analyses with measures of proteins. This research project provides students with biological samples to identify biomarkers of deconditioning and to isolate the biological effects of bedrest. Findings can be applied for the early detection of deconditioning in bedridden patients from a blood sample.
Organization:
Canadian Space Agency
Expected Results:
The Research component of the program provides financial support to organizations to conduct space related research
and development in priority areas. It will support targeted knowledge development and innovation to sustain and enhance the Canadian capacity to use space to address national needs and priorities in the
future.
Location:
Ottawa, Ontario, CA K1N 6N5
Reference Number:
003-2020-2021-Q1-04458
Report Type:
Grants and Contributions
Additional Information:
Initial end date : March 31, 2023
Amendment Date
Mar 17, 2022
Recipient's Legal Name:
University of Ottawa
Program:
Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Program Purpose:
This program supports knowledge development and innovation in the CSA's priority areas while increasing the awareness and participation of Canadians in space-related disciplines and activities.
The Research Component aims to support the development of science and technology; foster the continual development of a critical mass of researchers and highly qualified people in Canada; and support information gathering and space-related studies and research pertaining to Canadian Space Agency priorities.