Grants and Contributions:

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Title:

Tracking the mechanism of antibody trafficking across the blood brain barrier with advanced 3D-structure

Agreement Number:

925184

Agreement Value:

$25,000.00

Agreement Date:

Mar 15, 2019 - Mar 31, 2020

Description:

We will use Cryo-Electron Microscopy (McGill University) and Hydrogen-Deuterium Exchange Mass Spectrometry to study the mechanism by which antibodies bind to Insulin-like Growth Factor 1 Receptor (IGF1R) and cross the blood-brain barrier. Sophisticated models of receptor/antibody interactions will be constructed and used to decipher the molecular events that initiate crossing.

Organization:

National Research Council Canada

Expected Results:

In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators.

Location:

Montreal, Quebec, CA H3A 0G4

Reference Number:

172-2018-2019-Q4-00036

Agreement Type:

Grant

Report Type:

Grants and Contributions

Recipient Business Number:

119128981

Recipient Type:

Academia

Recipient's Operating Name:

The Royal Institution for the Advancement of Learning/McGill University

Recipient's Legal Name:

The Royal Institution for the Advancement of Learning/McGill University

Federal Riding Name:

Ville-Marie--Le Sud-Ouest--Île-des-Soeurs

Federal Riding Number:

24077

Program:

Collaborative Science, Technology and Innovation Program – Ideation Fund

Program Purpose:

The Ideation Fund is intended to encourage, test and validate transformative research ideas generated by teams of NRC scientific personnel and external collaborators with complementary capabilities, acting as a demonstration phase for a continually-evolving suite of research and development (R&D) deliverables at the NRC. The fund supports exploratory research through two mechanisms: the New Beginnings Initiative and the Small Teams Initiative.

NAICS Code:

541710 - R&D in the physical, engineering and life sciences