Grants and Contributions:

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Title:

Pathway Refractoring for Scale up to Commercial Yields of Fermentation-based Synthetic Chemical Production

Agreement Number:

938333

Agreement Value:

$63,000.00

Agreement Date:

Apr 1, 2019 - Jun 30, 2020

Description:

The overall objective of this project is to generate an optimized, high-yielding, commercial-scale alkaloid production technology based on yeast fermentation using existing Epimeron IP and building on previous R&D such as NRC-IRAP Projects 834944 and 861555. Although previous work has established a small-scale system capable of turning over alkaloid product, the yields fall short of commercial level titers (e.g. >10g/L). This proposal aims to (i) address dominant problems with current yeast production strains and (ii) improve titers, using inexpensive starting materials, to reach commercially feasible levels. Collaboration with a fermentation-specialized partnering firm will enable technology development in a scaled-up context.

Organization:

National Research Council Canada

Expected Results:

The purpose of IRAP Contributions to Firms is to support research, development, adoption and/or adaptation of innovative or technology-driven new or improved products, services or processes in Canada up to their commercialization

Location:

Calgary, Alberta, CA T2L 1Y8

Reference Number:

172-2019-2020-Q3-938333

Agreement Type:

Contribution

Report Type:

Grants and Contributions

Recipient Business Number:

120025523

Recipient Type:

For-profit organization

Recipient's Legal Name:

Willow Biosciences Inc.

Federal Riding Name:

Calgary Confederation

Federal Riding Number:

48005

Program:

Industrial Research Assistance Program – Contributions to Firms

Program Purpose:

Coverage:

IRAP Contributions to Firms projects stimulate wealth creation for Canada through technological innovation.

NAICS Code:

325410