Title:
Exploiting Collateral Sensitivity to Win the War Against Antimicrobial Resistance
Agreement Value:
$12,500.00
Agreement Date:
Mar 13, 2020 - Mar 31, 2021
Description:
Antimicrobial resistance (AMR) is a serious and growing problem in the treatment of infectious disease. Broadly, the potential to use combat AMR using collateral sensitivity, a phenomenon whereby resistance to one antimicrobial results in sensitivity to other drugs will be examined. The hypothesis that collateral sensitivities can be used to slow the emergence of AMR will be tested. The central premise of this hypothesis is that the use of one drug will select against mutations that confer resistance to a second drug. For example, if streptomycin resistance mutations confer sensitivity to chloramphenicol, then treatment of a sensitive population of bacteria with chloramphenicol should slow the emergence of streptomycin resistance by selecting against specific, collaterally sensitive mutations. The team will test this hypothesis using a combination of conventional mutation rate assays and sequencing. This work will provide crucial tests of the central logic of using collateral sensitivity to fight AMR; such tests have not thus far been carried out.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators.
Location:
Ottawa, Ontario, CA K1S 5B6
Reference Number:
172-2019-2020-Q4-946580
Report Type:
Grants and Contributions
Recipient Business Number:
118838937
Additional Information:
This agreement has been amended 1 time(s). The end date of this agreements has been modified by 152 days.
Recipient's Operating Name:
Carleton University
Recipient's Legal Name:
Carleton University
Federal Riding Name:
Ottawa Centre
Federal Riding Number:
35075
Program:
Collaborative Science, Technology and Innovation Program – Ideation Fund
Program Purpose:
The Ideation Fund is intended to encourage, test and validate transformative research ideas generated by teams of NRC scientific personnel and external collaborators with complementary capabilities, acting as a demonstration phase for a continually-evolving suite of research and development (R&D) deliverables at the NRC. The fund supports exploratory research through two mechanisms: the New Beginnings Initiative and the Small Teams Initiative.