Title:
A novel class of holocephalin heavy chain-only antibodies
Agreement Value:
$25,000.00
Agreement Date:
Mar 26, 2020 - Mar 31, 2021
Description:
A key component of the immune system of higher organisms are antibodies. Antibodies function to bind and eliminate infections. In addition to their natural immune system function, antibodies have emerged as a powerful type of drug to treat a variety of disease from cancer to the Ebola virus. While in the majority of vertebrates, antibodies consist of two protein chains (a heavy and light chain), there are three cases where antibodies have evolved to consist only of a heavy chain. These heavy-chain only antibodies are found in the camel family, two evolutionary branches of cartilaginous fishes. While the antibodies from camel and the elasmobranch (sharks) have been well characterized, to date, there has been no investigation into the heavy chain antibodies found in the holocephalin branch of cartilaginous fish. The goal of this project is to examine the atomic structure of holocephalin heavy-chain antibodies alone and in complex with the proteins which they bind. The structures will then be compared to camel and other mammal antibodies to determine if there are unique ways in which the holocephalin antibodies bind their targets.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators.
Location:
Fresno, US 93726
Reference Number:
172-2019-2020-Q4-946584
Report Type:
Grants and Contributions
Recipient Business Number:
N/A
Additional Information:
This agreement has been amended 1 time(s). The end date of this agreements has been modified by 60 days.
Recipient's Operating Name:
California State University, Fresno Foundation
Recipient's Legal Name:
California State University, Fresno Foundation
Federal Riding Number:
N/A
Program:
Collaborative Science, Technology and Innovation Program – Ideation Fund
Program Purpose:
The Ideation Fund is intended to encourage, test and validate transformative research ideas generated by teams of NRC scientific personnel and external collaborators with complementary capabilities, acting as a demonstration phase for a continually-evolving suite of research and development (R&D) deliverables at the NRC. The fund supports exploratory research through two mechanisms: the New Beginnings Initiative and the Small Teams Initiative.