Title:
3D bioprinting of a human based blood brain barrier model
Agreement Value:
$15,000.00
Agreement Date:
Mar 20, 2020 - Mar 31, 2021
Description:
The goal of this project is to develop alginate-based bioinks tailored for specific applications in bioprinting of complex 3D tissue models . These efforts will represent a continuation of recent work carried out by this team. The effects of different base alginate materials and cross-linking strategies on the mechanical properties of the resulting hydrogels will be tested. Hydrogels serve as the structural component for the spatial delivery of cells in bioprinted tissues. Their mechanical properties can impact cell responses and tissue construct integrity. The alginate molecules will also be modified to include biochemical signals that can be recognized by cells and direct their responses. This work will enable the ability to control the mechanical and biochemical environment of cells in bioprinted tissues. Development of the bioink toolkit will be done via an iterative process to address the needs of the fabrication and testing of the 3D tissue models.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators.
Location:
Ottawa, Ontario, CA K1N 6N5
Reference Number:
172-2019-2020-Q4-946585
Report Type:
Grants and Contributions
Recipient Business Number:
119278877
Additional Information:
This agreement has been amended 1 time(s). The end date of this agreements has been modified by 32 days. The total amended value is 113,500 dollars.
Recipient's Operating Name:
University of Ottawa
Recipient's Legal Name:
University of Ottawa
Federal Riding Name:
Ottawa–Vanier
Federal Riding Number:
35078
Program:
Collaborative Science, Technology and Innovation Program – Ideation Fund
Program Purpose:
The Ideation Fund is intended to encourage, test and validate transformative research ideas generated by teams of NRC scientific personnel and external collaborators with complementary capabilities, acting as a demonstration phase for a continually-evolving suite of research and development (R&D) deliverables at the NRC. The fund supports exploratory research through two mechanisms: the New Beginnings Initiative and the Small Teams Initiative.