Title:
3D bioprinting of a human based blood brain barrier model
Agreement Value:
$10,000.00
Agreement Date:
Mar 26, 2020 - Mar 31, 2021
Description:
Delivery of drugs to the central nervous system is hampered by the blood-brain barrier (BBB), a complex structure composed of multiple cells types and tissues that is subjected to forces due to blood flow. Current brain drug development relies on cells in dishes or animal models of the BBB that do not fully mimic human physiology and therefore cannot effectively predict whether a therapeutic will cross the BBB in a patient. Improved BBB models are necessary to overcome these challenges. To this end, the project will develop novel microfluidic chips into which laboratory BBB models can 3D bioprinted, grown, and used to test drug compounds in an environment that mimics key aspects of the human BBB. These platforms are expected to improve the drug development pipeline by reducing animal usage and drug development costs while improving the identification of promising drug candidates.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators.
Location:
Toronto, Ontario, CA M5S 1S8
Reference Number:
172-2019-2020-Q4-946586
Report Type:
Grants and Contributions
Recipient Business Number:
108162330
Additional Information:
This agreement has been amended 1 time(s). The end date of this agreements has been modified by 62 days.
Recipient's Operating Name:
The Governing Council of the University of Toronto
Recipient's Legal Name:
The Governing Council of the University of Toronto
Federal Riding Name:
University–Rosedale
Federal Riding Number:
35110
Program:
Collaborative Science, Technology and Innovation Program – Ideation Fund
Program Purpose:
The Ideation Fund is intended to encourage, test and validate transformative research ideas generated by teams of NRC scientific personnel and external collaborators with complementary capabilities, acting as a demonstration phase for a continually-evolving suite of research and development (R&D) deliverables at the NRC. The fund supports exploratory research through two mechanisms: the New Beginnings Initiative and the Small Teams Initiative.