Grants and Contributions:
Title:
Tracking the mechanism of antibody trafficking across the blood brain barrier with advanced 3D-structure
Agreement Number:
925184
Agreement Value:
$25,000.00
Agreement Date:
Mar 15, 2019 - Dec 31, 2020
Description:
We will use Cryo-Electron Microscopy (McGill University) and Hydrogen-Deuterium Exchange Mass Spectrometry to study the mechanism by which antibodies bind to Insulin-like Growth Factor 1 Receptor (IGF1R) and cross the blood-brain barrier. Sophisticated models of receptor/antibody interactions will be constructed and used to decipher the molecular events that initiate crossing.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Montreal, Quebec, CA H3A 0G4
Reference Number:
172-2020-2021-Q3-925184
Agreement Type:
Grant
Report Type:
Grants and Contributions
Recipient Business Number:
119128981
Recipient Type:
Academia
Additional Information:
This agreement has been amended 2 time(s). The end date of this agreements has been modified by 181 days.
Amendment Date
Dec 14, 2020
Recipient's Legal Name:
The Royal Institution for the Advancement of Learning/McGill University
Federal Riding Name:
Ville-Marie–Le Sud-Ouest–Île-des-Sœurs
Federal Riding Number:
24077
Program:
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Purpose:
Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.
NAICS Code:
541746
Amendments: