Grants and Contributions:
Title:
Development of a scalable upstream process for SARS-CoV-2 spike protein production in bioreactors
Agreement Number:
965937
Agreement Value:
$492,387.00
Agreement Date:
Feb 7, 2021 - Mar 31, 2022
Description:
The spike protein (S protein) of the pandemic coronavirus (SARS-CoV-2) is the antigen of choice for use in vaccines and serological diagnostic tests. There is thus a pressing need to develop a robust bioprocess allowing scale-up of spike protein production. One of the main challenges in upstream cell culture bioprocessing is to translate small-scale production protocols from laboratory to large-scale bioreactor. A fundamental understanding of the mixing/aeration process is essential for successful process scale-up, as this will ultimately dictate the performance of the culture and the final product yield. This Project aims at defining efficient bioreactor operating strategies to maximize the productivity of a stable transfected pool expressing the SARS-CoV-2 spike protein. The knowledge derived from this Project will allow to guide the operation of pilot-scale (and beyond) bioreactors, thereby speeding-up NRC’s capacity to mass produce the S protein required for vaccine and diagnostic applications.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Montreal, Quebec, CA H3T 1J4
Reference Number:
172-2020-2021-Q4-965937
Agreement Type:
Grant
Report Type:
Grants and Contributions
Recipient Business Number:
107585226
Recipient Type:
Academia
Additional Information:
Belated reporting: This agreement has been amended 1 time(s). The end date of this agreement has been modified by 89 days.
Amendment Date
Jan 20, 2022
Recipient's Legal Name:
Corporation de l'École Polytechnique de Montréal
Federal Riding Name:
Outremont
Federal Riding Number:
24054
Program:
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Purpose:
Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.
NAICS Code:
541710
Amendments: