Grants and Contributions:
Title:
Bioengineering of artificial lung niches: recapitulating pulmonary fibrosis and pathophysiology
Agreement Number:
967236
Agreement Value:
$25,000.00
Agreement Date:
Mar 11, 2021 - Sep 30, 2022
Description:
The body responds to injury in several ways. While the healing process begins by replacing damaged tissue with cells of the same
type, this phase is typically followed by fibrosis, wherein normal tissues are replaced by connective tissue. The result is overgrowth,
hardening, and/or scarring of various tissues, such as lungs, liver, heart, and brain, and is attributed to excessive deposition of
collagen. Current histological methods for analyzing the changes happening within the extracellular matrix (ECM) cannot accurately
resolve the biochemical and 3D structural composition of specific proteins and components. We will be responsible for assessing the
models developed at the NRC using super-resolution optical microscopy techniques as well as transmission electron microscopy
(TEM) to assess 3D structural features of ECM molecules. We will be responsible for acquiring such images and develop new image
analysis methods to assess how the fibers and fibrils morphology are altered, as well as establish metrics to capture the 3D structure
of the bioprinted tissue fibers.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators.
Location:
Ottawa, Ontario, CA K1S 5B6
Reference Number:
172-2020-2021-Q4-967236
Agreement Type:
Grant
Report Type:
Grants and Contributions
Recipient Business Number:
118838937
Recipient Type:
Academia
Recipient's Legal Name:
Carleton University
Federal Riding Name:
Ottawa Centre
Federal Riding Number:
35075
Program:
Collaborative Science, Technology and Innovation Program – Ideation Fund
Program Purpose:
The Ideation Fund is intended to encourage, test and validate transformative research ideas generated by teams of NRC scientific personnel and external collaborators with complementary capabilities, acting as a demonstration phase for a continually-evolving suite of research and development (R&D) deliverables at the NRC. The fund supports exploratory research through two mechanisms: the New Beginnings Initiative and the Small Teams Initiative.
NAICS Code:
541710 - R&D in the physical, engineering and life sciences