Grants and Contributions:

Title:

Elucidating Endocannabinoid Receptor Dynamics in Response to Exogenous Cannabinoid Binding with Structural Mass Spectrometry

Agreement Number:

967241

Agreement Value:

$25,000.00

Agreement Date:

Mar 26, 2021 - Sep 30, 2022

Description:

The type 1 cannabinoid receptor (CB1R) is the receptor that is activated by .9-tetrahydrocannabinol (THC), the chemical in Cannabis that produces the 'high' Cannabis users experience. THC, and the related cannabidiol (CBD) are known as a cannabinoids and at least 120 other cannabinoids have been identified in the Cannabis plant. Cannabinoids are being explored for their potential use to treat epilepsy, pain, anxiety, and numerous other ailments. Unfortunately, our knowledge of how cannabinoids work at CB1R is limited. In this project, we will use computer-assisted drug design programs and drug discovery experiments to understand how cannabinoids from the Cannabis plant work at the molecular level. Mutant forms of the receptor will be used to help us understand which parts of CB1R are required for cannabinoids to produce cellular effects. From this study we will gain critical knowledge about how cannabinoids work with CB1R. This knowledge will lead to improved understanding of cannabinoid biology, safe and effective use of cannabinoids, and the potential for new cannabinoid drugs.

Organization:

National Research Council Canada

Expected Results:

In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators.

Location:

Saskatoon, Saskatchewan, CA S7N 5A2

Reference Number:

172-2020-2021-Q4-967241

Agreement Type:

Grant

Report Type:

Grants and Contributions

Recipient Business Number:

119279313

Recipient Type:

Academia

Recipient's Legal Name:

University of Saskatchewan

Federal Riding Name:

Saskatoon–University

Federal Riding Number:

47011

Program:

Collaborative Science, Technology and Innovation Program – Ideation Fund

Program Purpose:

The Ideation Fund is intended to encourage, test and validate transformative research ideas generated by teams of NRC scientific personnel and external collaborators with complementary capabilities, acting as a demonstration phase for a continually-evolving suite of research and development (R&D) deliverables at the NRC. The fund supports exploratory research through two mechanisms: the New Beginnings Initiative and the Small Teams Initiative.

NAICS Code:

541710 - R&D in the physical, engineering and life sciences