Grants and Contributions:
Title:
Structural studies of SARS-CoV-2 spike protein domains bound to engineered glycan receptors and ACE2 fragments
Agreement Number:
968073
Agreement Value:
$95,370.00
Agreement Date:
Mar 3, 2021 - Feb 28, 2022
Description:
SARS-CoV-2 spike protein plays a critical role in initiating the infection process. There is evidence that in addition to the recognition of its receptor binding domain (RBD) by human ACE2 receptor, interactions of the N-terminal domain (NTD) with the sialic acid-based glycan receptors lining the respiratory tract are important to trigger its binding to ACE2, but structural determinants of this recognition remain elusive. As the atomic details of these interactions could be exploited to design and optimize therapeutic candidates, the Recipient will determine a series of crystal structures of spike domains complexed with various ACE2-derived peptides and glycan carbohydrates. Structural data generated will provide a solid basis for further engineering of both peptides and glycans with incremental improvements of binding and neutralization properties to the SARS-CoV-2 spike protein, paving the way for development of therapeutic candidates that can address not only the current pandemic but also future challenges.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Quebec, Quebec, CA G1V 0A6
Reference Number:
172-2020-2021-Q4-968073
Agreement Type:
Grant
Report Type:
Grants and Contributions
Recipient Business Number:
119278950
Recipient Type:
Academia
Additional Information:
Belated reporting: This agreement has been amended 1 time(s). The total amended value is $95,370.
Amendment Date
Jan 20, 2022
Recipient's Legal Name:
Université Laval
Federal Riding Name:
Louis-Hébert
Federal Riding Number:
24044
Program:
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Purpose:
Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.
NAICS Code:
541710
Amendments: