Title:
Bacterial SOS and non-SOS responses to antibiotics in A. baumannii
Agreement Value:
$56,603.46
Agreement Date:
Mar 2, 2021 - Feb 23, 2024
Description:
Antibiotic microbial resistance (AMR) is serious concern as bacteria have evolved to resist many of the current antibiotic drugs. Of particular concern are Gram negative bacteria such as Acinetobacter baumannii which is often the cause of outbreaks in health care settings. The Project will develop novel, “plug-and-play” biodegradable nanoparticles and bioengineered phage delivery systems for targeting bacterial cell surfaces of AMR pathogens to repurpose existing antibiotics for combating AMR. A key component of these delivery systems is the bacteriophage-based delivery system to increase the sensitivity of AMR pathogens to antibiotics, thereby repurposing the currently licensed antibiotics as a strategy to combat AMR crisis. Many bactericidal antibiotics lead to formation of hydroxyl radicals, resulting in damage to DNA, proteins and lipids and subsequent induction of the SOS response. The Project will specifically identify genes that are critical to the bacterial SOS or non-SOS responses to antibiotics and then clone those genes to bacteriophages as a way to reduce their antibiotics resistance.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Reference Number:
172-2020-2021-Q4-968516
Report Type:
Grants and Contributions
Recipient Business Number:
000000000
Recipient's Legal Name:
Emory University
Program:
Collaborative Science, Technology and Innovation Program – Ideation Fund
Program Purpose:
The Ideation Fund is intended to encourage, test and validate transformative research ideas generated by teams of NRC scientific personnel and external collaborators with complementary capabilities, acting as a demonstration phase for a continually-evolving suite of research and development (R&D) deliverables at the NRC. The fund supports exploratory research through two mechanisms: the New Beginnings Initiative and the Small Teams Initiative.
NAICS Code:
541710 - R&D in the physical, engineering and life sciences