Grants and Contributions:
Title:
Automated library preparation from clinical samples for distributed genome sequencing and detection of viruses.
Agreement Number:
969536
Agreement Value:
$490,287.00
Agreement Date:
Mar 29, 2021 - Mar 30, 2022
Description:
The aim of this Project is to generate flexible-use, automated devices for rapid and efficient SARS-CoV-2 genome sequencing in order to enable early detection and molecular epidemiology studies to inform public health policies. The device will be based on the PowerBlade system and should be able to perform complex molecular steps, from virus RNA reverse transcription, to PCR amplification and library preparation for rapid sequencing by nanopore technology. The Loop-mediated isothermal amplification (LAMP) reaction will also be adopted in combination with nanopore sequencing and applied in the form of a sequencing based rapid molecular test. These devices will be suitable for rapid deployment in the case of COVID-19 threats, as well as future threats in public health laboratories, diagnostic laboratories in hospitals, genomics laboratories and sequence service providers in academia, and the private sector, as well as suitable for point-of-need deployment, including remote locations. The combination of PowerBlade and Nanopore represents a potential flexible, mobile solution, which allows deployment in locations that do not have substantial genomics infrastructure, and therefore, enables the wide use of this system. This should enable low cost-fast turnaround genome sequencing and targeted sequencing in order to identify high risk SARS-CoV-2 virus variants in response to outbreaks and inform public health authorities.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Montreal, Quebec, CA H3A 0G4
Reference Number:
172-2020-2021-Q4-969536
Agreement Type:
Grant
Report Type:
Grants and Contributions
Recipient Business Number:
119128981
Recipient Type:
Academia
Recipient's Legal Name:
The Royal Institution for the Advancement of Learning/McGill University
Federal Riding Name:
Ville-Marie–Le Sud-Ouest–Île-des-Sœurs
Federal Riding Number:
24077
Program:
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Purpose:
Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.
NAICS Code:
541710 - R&D in the physical, engineering and life sciences