Title:
Neuroprotective peptides for stroke
Agreement Value:
$25,000.00
Agreement Date:
Jun 22, 2021 - Sep 30, 2022
Description:
Dr Blondeau’s laboratory at the CNRS in France will perform the in vivo experiments to evaluate the neuroprotective efficacy of biologics against cerebral ischemia. Two biologics will be tested, as identified in in vitro screening experiments. The model of cerebral ischemia employed by Dr Blondeau’s laboratory will be transient middle occlusion cerebral artery (tMCAO) with re-perfusion. Temperature will be regulated and blood flow will be monitored by laser-doppler flowmetry. The tMCAO model produces a reproducible lesion volume large enough to allow detection of protective effects = 20%. To test neuroprotection, the biologic will be injected in the carotid artery (using the same artery that was occluded) at the onset of re-perfusion. Outcomes measured will be lesion volumes (which generally correlates with clinical neuroimaging), region specific neuronal loss and behavioral tests. The experiments performed at the CNRS will identify the most neuroprotective biologic.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
SOPHIA Antipolis Cedex, FR
Reference Number:
172-2021-2022-Q1-973706
Report Type:
Grants and Contributions
Recipient Business Number:
108161266
Recipient's Legal Name:
National Center for Scientific Research
Program:
Collaborative Science, Technology and Innovation Program – Ideation Fund
Program Purpose:
The Ideation Fund is intended to encourage, test and validate transformative research ideas generated by teams of NRC scientific personnel and external collaborators with complementary capabilities, acting as a demonstration phase for a continually-evolving suite of research and development (R&D) deliverables at the NRC. The fund supports exploratory research through two mechanisms: the New Beginnings Initiative and the Small Teams Initiative.
NAICS Code:
541710 - R&D in the physical, engineering and life sciences