Grants and Contributions:
Title:
High resolution immunometabolomics for the discovery and verification of biomarkers of CAR-T efficacy
Agreement Number:
974328
Agreement Value:
$174,680.00
Agreement Date:
Jul 1, 2021 - Jun 30, 2025
Description:
Chimeric antigen receptor T-cells (CAR-T) are used to treat a variety of cancer. However, unlike well-defined drugs such as chemicals and antibodies, CAR-T are complex, living therapies. Therefore, it is difficult to objectively assess the potency of CAR-T. The overall objective of this project is to determine immunometabolomic biomarkers that can be measured prior to infusion of CAR-T into patients in order to predict the treatment efficacy for each patient.
The metabolic profile of all cells is determined by both their genomic makeup as well as their interaction with the environment. Unlike genomic profiles, the metabolomic profile can react rapidly to changes in nutrients, additives and other products added during the production of CAR-T cells from a patient’s own T-cells. Immunometabolomics can be used to rapidly and quantitatively profile hundreds of metabolites. By deploying advanced immunometabolomic techniques to the analysis of CAR-T cells in the context of on-going pre-clinical and clinical trials, we aim to identify robust immunometabolomic biomarkers of CAR-T efficacy.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Halifax, Nova Scotia, CA B3H 4R2
Reference Number:
172-2021-2022-Q1-974328
Agreement Type:
Grant
Report Type:
Grants and Contributions
Recipient Business Number:
886806561
Recipient Type:
Academia
Additional Information:
This agreement has been amended 2 time(s). The end date of this agreement has been modified by 365 days.
Amendment Date
Jun 17, 2024
Recipient's Legal Name:
Dalhousie University
Federal Riding Name:
Halifax
Federal Riding Number:
12006
Program:
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Purpose:
Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.
NAICS Code:
541710 - R&D in the physical, engineering and life sciences
Amendments: