Grants and Contributions:
Title:
Microbead-in-droplet assay for characterizing chimeric antigen receptor t-cells activation by tumor cells in co-culture droplets
Agreement Number:
979803
Agreement Value:
$150,000.00
Agreement Date:
Oct 1, 2021 - Jun 30, 2023
Description:
The project aims to characterize the functionality of engineered immune cells (e.g. CAR T-cells) by activating them with tumor-specific antigens (e.g. CD-19) and through their interaction with isolated circulating tumor cells (CTCs). To achieve this goal, the CAR T-cells and the isolated cells will be brought together and encapsulated in droplets to promote cellular interactions. The cells will then be incubated for CAR T-cell activation, and the activated CAR T-cells will be interrogated by analyzing the cytokines output using a microbead-in-droplet multiplex sandwich immunoassay developed in this project. The novel technology proposed herein is currently unavailable on the market and has the potential to significantly affect the
way that cell therapy products are assessed and how quality control is performed.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Montreal, Quebec, CA H3A 0G4
Reference Number:
172-2021-2022-Q1-979803
Agreement Type:
Grant
Report Type:
Grants and Contributions
Recipient Business Number:
119128981
Recipient Type:
Academia
Additional Information:
This agreement has been amended 1 time(s). The total amended value is $150,000
Amendment Date
Mar 28, 2023
Recipient's Legal Name:
The Royal Institution for the Advancement of Learning/McGill University
Federal Riding Name:
Ville-Marie–Le Sud-Ouest–Île-des-Sœurs
Federal Riding Number:
24077
Program:
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Purpose:
Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.
NAICS Code:
541710
Amendments: