Grants and Contributions:
Title:
Precision targeted mRNA lipid/lipid-polymer nanoparticles for modulation of the tumor microenvironment (TME)
Agreement Number:
987590
Agreement Value:
$200,000.00
Agreement Date:
Feb 28, 2022 - Mar 31, 2025
Description:
The tumor microenvironment (TME) is immunosuppressive and presents many challenges to cancer therapies. Modulating TME to be less immunosuppressive will block tumor immune escape and enhance the effects of cancer immunotherapies such as T-cell therapies. However, TME modulating agents need to be selectively delivered to the tumors to protect them from degradation and inducing unwanted toxicity to healthy organs. This project will develop novel nanoparticle systems containing TME modulating messenger RNA (mRNA) and selectively deliver them to tumors to modulate the TME. The team will assess the therapeutic effects of our mRNA-nanoparticle systems in clinically relevant in vitro and in vivo
models. If successful in modulating the TME to be less immunosuppressive, the proposed technologies will have tremendous potential in the advancement of future CAR-T or other types of cellular immunotherapies for solid tumours.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Ottawa, Ontario, CA K1N 6N5
Reference Number:
172-2021-2022-Q4-987590
Agreement Type:
Grant
Report Type:
Grants and Contributions
Recipient Business Number:
119278877
Recipient Type:
Academia
Additional Information:
This agreement has been amended 1 time(s). The end date of this agreement has been modified by 364 days.
Amendment Date
Feb 27, 2024
Recipient's Legal Name:
University of Ottawa
Federal Riding Name:
Ottawa–Vanier
Federal Riding Number:
35078
Program:
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Purpose:
Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.
NAICS Code:
541710 - R&D in the physical, engineering and life sciences
Amendments: