Title:
Glycosphingolipids and phospholipids as novel danger signals for activation of the NLRP3 inflammasome in prodromal Parkinson’s disease
Agreement Value:
$25,000.00
Agreement Date:
Mar 11, 2021 - Mar 31, 2023
Description:
Dysfunctional innate immune system, aberrant lipid metabolism and chronic inflammation plays a pivotal role in the development of neurodegenerative diseases. We aim to use quantitative neurolipidomics (uOttawa) to identify novel "lipid signatures" that can act as sterile triggers to activate inflammatory responses and leverage antibody-based therapeutics (NRC) to extinguish the fire of inflammation.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Ottawa, Ontario, CA K1N 6N5
Reference Number:
172-2022-2023-Q2-967243
Report Type:
Grants and Contributions
Recipient Business Number:
119278877
Additional Information:
This agreement has been amended 1 time(s). The end date of this agreements has been modified by 182 days
Amendment Date
Aug 10, 2022
Recipient's Legal Name:
University of Ottawa
Federal Riding Name:
Ottawa--Vanier
Federal Riding Number:
35078
Program:
Collaborative Science, Technology and Innovation Program – Ideation Fund
Program Purpose:
The Ideation Fund is intended to encourage, test and validate transformative research ideas generated by teams of NRC scientific personnel and external collaborators with complementary capabilities, acting as a demonstration phase for a continually-evolving suite of research and development (R&D) deliverables at the NRC. The fund supports exploratory research through two mechanisms: the New Beginnings Initiative and the Small Teams Initiative.