Grants and Contributions:
Title:
Selection and characterization of humanized antibody candidate for the treatment of kappa light chain amyloidosis
Agreement Number:
994401
Agreement Value:
$30,000.00
Agreement Date:
Aug 8, 2022 - Feb 28, 2023
Description:
AL amyloidosis is a life-threatening disease caused by the misfolding of free immunoglobulin light chains (LC) which deposit as light chain amyloid (AL) in the heart, kidney, and nervous system, causing organ failure and death. There are currently no existing therapies that direct remove these deposits from organs. We have identified a murine monoclonal antibody, LX-96, that specifically binds to misfolded and aggregated light chains of the kappa isotype, while ignoring the native light chain or intact immunoglobulins. The goal of this project is to humanize murine LX-96 and select a humanized developmental candidate for downstream manufacturing and IND-enabling toxicity studies through in-house and commercial screening assays.
Organization:
National Research Council Canada
Expected Results:
The purpose of IRAP’s Youth Employment Program is to assist in increasing the supply of highly qualified people, promoting the benefits of advanced studies, demonstrating federal leadership by investing in the skills required to meet the needs of the knowledge economy and facilitating the transition of highly skilled young people to a rapidly changing labour market.
Location:
Toronto, Ontario, CA M5G 0B7
Reference Number:
172-2022-2023-Q2-994401
Agreement Type:
Contribution
Report Type:
Grants and Contributions
Recipient Business Number:
758832877
Recipient Type:
For-profit organization
Recipient's Legal Name:
Paradox Immunotherapeutics Incorporated
Federal Riding Name:
University--Rosedale
Federal Riding Number:
35110
Program:
Industrial Research Assistance Program – Youth Employment Program
Program Purpose:
The purpose of IRAP’s Youth Employment Program is to assist in increasing the supply of highly qualified people, promoting the benefits of advanced studies, demonstrating federal leadership by investing in the skills required to meet the needs of the knowledge economy and facilitating the transition of highly skilled young people to a rapidly changing labour market.
Coverage:
IRAP Youth Employment Program projects stimulate wealth creation for Canada through technological innovation.
NAICS Code:
54171