Title:
Clinical CAR-T cell raman spectroscopy analysis
Agreement Value:
$327,103.00
Agreement Date:
Aug 1, 2022 - Nov 30, 2025
Description:
The approval of chimeric antigen receptor T-cell (CAR-T) therapies has been a major breakthrough for patients with relapsed or refractory blood cancers. However, CAR-T cells are highly complex, live cell therapies, and it has proven difficult to predict CAR-T cell potency. Great improvements in laser and detector technologies have led to an explosive growth in biomedical applications of Raman spectroscopy (RS), including leading contributions by this group. RS measures the macromolecular changes in T cells that are phenotypical of their activation state and other changes. The objective of this project is to contribute to the NRC search for potency biomarkers, based on the RS analysis of CLIC-01 patient cell samples taken prior to infusion. This contributes a novel and orthogonal analytical dimension to the overall NRC search for biomarkers that predict the efficacy of the treatment for each patient, and thereby when costly CAR-T cell treatments should be performed
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Vancouver, British Columbia, CA V6T 1Z3
Reference Number:
172-2022-2023-Q2-996027
Report Type:
Grants and Contributions
Recipient Business Number:
108161779
Additional Information:
This agreement has been amended 2 time(s) the total amended value is $327,103.The end date of this agreement has been modified by 243 days.
Amendment Date
Feb 26, 2025
Recipient's Legal Name:
The University of British Columbia
Federal Riding Name:
Vancouver Quadra
Federal Riding Number:
59040
Program:
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Purpose:
Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.