Title:
ARIADNE: platform for Accelerated and pRecisIon pAndemic Diagnostics and iNfection hEalth.
Agreement Number:
1028742
Agreement Value:
$352,200.00
Agreement Date:
Mar 17, 2025 - Mar 17, 2028
Description:
The overall goal is to develop “ARIADNE” (platform for Accelerated and pRecisIon pAndemic Diagnostics and iNfection hEalth), a novel decentralized molecular analytical tool for deployment in the ‘non-expert’ care settings for timely stratification and triage of patients. The proof-of-principle work will target sepsis, a complex and heterogeneous life-threatening dysregulated response to infection that rapidly progresses to multi-organ failure and death when not identified and treated appropriately. It integrates NRC's microfluidic technology (PowerBlade) with novel gene circuit-based molecular sensors, facilitated by machine learning algorithms for biomarker refinement. This project leverages unique strengths of the multidisciplinary collaboration that combines the clinical translational capacity of our team at St. Michael’s Hospital (University of Toronto), synthetic biology expertise and molecular sensor chemistry at the UoT and Boston University, the bioinformatics know-how of our collaborators at Simon Fraser University, ML expertise at DT, NRC’s unique microfluidic technology developed by the MD group.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Toronto, Ontario, CA M5B 1W8
Reference Number:
172-2024-2025-Q4-1028742
Report Type:
Grants and Contributions
Recipient Business Number:
108032533
Recipient's Legal Name:
Unity Health Toronto
Federal Riding Name:
Toronto Centre
Federal Riding Number:
35109
Program:
Collaborative Science, Technology and Innovation Program – Ideation Fund
Program Purpose:
The Ideation Fund is intended to encourage, test and validate transformative research ideas generated by teams of NRC scientific personnel and external collaborators with complementary capabilities, acting as a demonstration phase for a continually-evolving suite of research and development (R&D) deliverables at the NRC. The fund supports exploratory research through two mechanisms: the New Beginnings Initiative and the Small Teams Initiative.