Grants and Contributions:

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Title:
Evaluating the efficacy and toxicity of intratumoural administration of an anti-EGFR CAR-T therapy in pre-clinical models of cutaneous squamous cell carcinoma
Agreement Number:
1029941
Agreement Value:
$258,346.00
Agreement Date:
May 1, 2025 - Mar 30, 2026
Description:
Patients with advanced cutaneous squamous cell carcinoma (cSCC) who are not eligible for or have failed to respond to anti-PD1 immunotherapy have few treatment options. Epidermal growth factor receptor (EGFR) directed chimeric antigen receptor -T cell (CAR-T) therapy is a promising strategy; however, off-target toxicity remains a major obstacle due to expression in healthy tissues. To address this concern, the use of intratumoural (IT) administration of NRC’s novel nanobody-based EGFR CAR-T will be evaluated in the pre-clinical model of cSCC. The aims of the study will be to determine the dosage required for tumour control and evaluate the trafficking and functional T-cell phenotypes in IT administration. It is expected that IT administration will lead to substantially fewer CAR-T cells in all biological compartments than traditional intravenous (IV) administration, and that direct injection of cells will result in different T-cell populations within the tumour.
Organization:
National Research Council Canada
Expected Results:

In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.

Location:
Toronto, Ontario, CA M5G 2C4
Reference Number:
172-2025-2026-Q1-1029941
Agreement Type:
Grant
Report Type:
Grants and Contributions
Recipient Business Number:
119259505
Recipient Type:
Not-for-profit organization or charity
Recipient's Legal Name:
University Health Network
Federal Riding Name:
University--Rosedale
Federal Riding Number:
35112
Program:
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Purpose:

Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.

NAICS Code:
541710