Grants and Contributions:
Title:
Innovative Strategies for Non-Viral Generation of iPSC-Derived CAR-T Therapies
Agreement Number:
1031592
Agreement Value:
$200,057.00
Agreement Date:
Jul 1, 2025 - Dec 31, 2025
Description:
The NRC has created human amniotic fluid-derived iPSCs (HAF-iPSCs) to produce functional T cells for adoptive therapies. This Project aims to validate and optimize the differentiation of HAF-iPSCs into CD4+ and CD8+ T cells, evaluating their performance against established iPSC lines. To facilitate evaluation of therapeutic potential, an in vitro microcontact printing platform will be developed for high-throughput characterization of iPSC-T cells' ligand binding responses and cytokine release profiles. Additionally, the Project will explore using self-amplifying RNA (saRNA) and NRC’s lipid nanoparticle technology to deliver CARs, targeting BCMA for blood cancers and EGFR for solid tumors, ensuring stable expression and functionality across various cell lines. These efforts seek to create offthe-shelf iPSC-derived CAR-T cells with predictable therapeutic response and means to screen their functional profiles.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Vancouver, British Columbia, CA V6T 1Z3
Reference Number:
172-2025-2026-Q2-1031592
Agreement Type:
Grant
Report Type:
Grants and Contributions
Recipient Business Number:
108161779
Recipient Type:
Academia
Recipient's Legal Name:
The University of British Columbia
Federal Riding Name:
Vancouver Quadra
Federal Riding Number:
59040
Program:
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Purpose:
Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.
NAICS Code:
541710