Title:
Engineering Phages with Improved Host Ranges for Better Therapeutic Efficacy
Agreement Number:
1033219
Agreement Value:
$323,400.00
Agreement Date:
Oct 1, 2025 - Mar 31, 2028
Description:
The broader adoption of phage therapy for antimicrobial resistant infections is challenging due to the significant time required to screen for phage candidates, propagate them, purify them, and perform the required quality controls. This procedure can take upwards of 25 days and requires highly trained personnel. To overcome this challenge, this collaboration aims to develop a phage engineering platform and design phages capable of infecting a broader range of clinicalP. aeruginosa isolates to facilitate the deployment of phage therapy.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Toronto, Ontario, CA M5S 1S8
Reference Number:
172-2025-2026-Q4-1033219
Report Type:
Grants and Contributions
Recipient Business Number:
108162330
Recipient's Legal Name:
The Governing Council of the University of Toronto
Federal Riding Name:
University--Rosedale
Federal Riding Number:
35112
Program:
Collaborative Science, Technology and Innovation Program – Ideation Fund
Program Purpose:
The Ideation Fund is intended to encourage, test and validate transformative research ideas generated by teams of NRC scientific personnel and external collaborators with complementary capabilities, acting as a demonstration phase for a continually-evolving suite of research and development (R&D) deliverables at the NRC. The fund supports exploratory research through two mechanisms: the New Beginnings Initiative and the Small Teams Initiative.
NAICS Code:
541710 - R&D in the physical, engineering and life sciences