Title:
Tracking the mechanism of antibody trafficking across the blood brain barrier with advanced 3D-structure
Agreement Value:
$25,000.00
Agreement Date:
May 29, 2020 - Dec 31, 2020
Description:
We will use Cryo-Electron Microscopy (McGill University) and Hydrogen-Deuterium Exchange Mass Spectrometry to study the mechanism by which antibodies bind to Insulin-like Growth Factor 1 Receptor (IGF1R) and cross the blood-brain barrier. Sophisticated models of receptor/antibody interactions will be constructed and used to decipher the molecular events that initiate crossing.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators.
Location:
Montreal, Quebec, CA H3A 0G4
Reference Number:
172-2020-2021-Q1-925184
Report Type:
Grants and Contributions
Recipient Business Number:
119128981
Additional Information:
This agreement has been amended 1 time(s). The end date of this agreements has been modified by 275 days.
Amendment Date
May 29, 2020
Recipient's Legal Name:
The Royal Institution for the Advancement of Learning/McGill University
Federal Riding Name:
Ville-Marie–Le Sud-Ouest–Île-des-Sœurs
Federal Riding Number:
24077
Program:
Collaborative Science, Technology and Innovation Program – Ideation Fund
Program Purpose:
The Ideation Fund is intended to encourage, test and validate transformative research ideas generated by teams of NRC scientific personnel and external collaborators with complementary capabilities, acting as a demonstration phase for a continually-evolving suite of research and development (R&D) deliverables at the NRC. The fund supports exploratory research through two mechanisms: the New Beginnings Initiative and the Small Teams Initiative.
NAICS Code:
541710 - R&D in the physical, engineering and life sciences