Grants and Contributions:
Title:
Reprogramming the human genome through targeted genomic integration of synthetic DNA
Agreement Number:
961445
Agreement Value:
$224,200.00
Agreement Date:
Jan 1, 2021 - Apr 30, 2024
Description:
The overall objective of this Project is to develop the technology and expertise necessary for reprogramming the human genome through targeted integration of recombinant DNA within induced-pluripotent stem cells (iPSCs). This Project aims to leverage the innate programming of the human genome by performing integration of therapeutic genes, such as chimeric antigen receptors (CAR), into targeted sites. These tools will be key to the deployment and validation of NRC’s self-cleaving and integrating plasmid (pSCIP) technology towards engineering iPSC-derived CAR-Natural Killer (NK) cells that will prevent treatment-associated toxicity and immune-mediated adverse events and help expedite preclinical proof of concept studies for targeting solid tumors such as triple negative breast cancer.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Ottawa, Ontario, CA K1N 6N5
Reference Number:
172-2020-2021-Q3-961445
Agreement Type:
Grant
Report Type:
Grants and Contributions
Recipient Business Number:
119278877
Recipient Type:
Academia
Additional Information:
This agreement has been amended 2 time(s). The end date of this agreement has been modified by 242 days.
Amendment Date
Nov 20, 2023
Recipient's Legal Name:
University of Ottawa
Federal Riding Name:
Ottawa–Vanier
Federal Riding Number:
35078
Program:
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Purpose:
Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.
NAICS Code:
541710 - R&D in the physical, engineering and life sciences
Amendments: