Title:
Phages of Acinetobacter baumannii
Agreement Value:
$195,000.00
Agreement Date:
Dec 22, 2020 - Jan 15, 2024
Description:
In order to provide effective antibiotics, it is critical that Canada find mechanisms to deal with antibiotic microbial resistance (AMR). In the Project, the goal is to develop a novel phage-based antibiotic delivery system as an alternative to antimicrobials. The Project will include collaborative research between Université Laval and NRC to use the developed phage collection and in vitro phage assays to explore targeted delivery.
The Project will perform genome engineering of lead phages to modulate virulence, optimize host range of clinical isolates and minimize resistance development. These efforts are expected to help evaluate the functions of genes/proteins from selected Acinetobacter baumannii lytic phages, for potential therapy as alternatives to antibiotics.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Laval, Quebec, CA G1V 0A6
Reference Number:
172-2020-2021-Q3-963362
Report Type:
Grants and Contributions
Recipient Business Number:
119278950
Recipient's Legal Name:
Université Laval
Federal Riding Name:
Louis-Hébert
Federal Riding Number:
24044
Program:
Collaborative Science, Technology and Innovation Program – Ideation Fund
Program Purpose:
The Ideation Fund is intended to encourage, test and validate transformative research ideas generated by teams of NRC scientific personnel and external collaborators with complementary capabilities, acting as a demonstration phase for a continually-evolving suite of research and development (R&D) deliverables at the NRC. The fund supports exploratory research through two mechanisms: the New Beginnings Initiative and the Small Teams Initiative.