Grants and Contributions:

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Title:

Optical tuning of lanthanide nanoparticles for novel theranostics

Agreement Number:

967233

Agreement Value:

$25,000.00

Agreement Date:

Mar 11, 2021 - Sep 30, 2022

Description:

Lanthanide-doped nanoparticles (Ln-NPs) are an emerging class of nanomaterials with light shifting properties that make them highly attractive materials for use in biomedical diagnosis and therapeutic intervention. Herein, understanding of their optical properties when interacting with biological systems is an important step towards the design of more efficient probes, The aim of this collaborative project is the design of such more efficient optical probes, while setting a strong focus on the assessment of the probes' cytotoxicity and nano-bio-interaction. In order to achieve our goal, i.e. the design of small-yet-bright and safe-to-use optical bioprobes (Ln-NPs), research at the HemmerLab will focus on the synthesis and surface modification of inorganic lanthanide-doped nanoparticles and their structural and optical characterization. Herein, we will use the emerging technique of hyperspectral imaging in order to gain insight into environment-specific photoluminescence of the Ln-NPs incubated with various biological cells.

Organization:

National Research Council Canada

Expected Results:

In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators.

Location:

Ottawa, Ontario, CA K1N 6N5

Reference Number:

172-2020-2021-Q4-967233

Agreement Type:

Grant

Report Type:

Grants and Contributions

Recipient Business Number:

119278877

Recipient Type:

Academia

Recipient's Legal Name:

University of Ottawa

Federal Riding Name:

Ottawa–Vanier

Federal Riding Number:

35078

Program:

Collaborative Science, Technology and Innovation Program – Ideation Fund

Program Purpose:

The Ideation Fund is intended to encourage, test and validate transformative research ideas generated by teams of NRC scientific personnel and external collaborators with complementary capabilities, acting as a demonstration phase for a continually-evolving suite of research and development (R&D) deliverables at the NRC. The fund supports exploratory research through two mechanisms: the New Beginnings Initiative and the Small Teams Initiative.

NAICS Code:

541710 - R&D in the physical, engineering and life sciences