Grants and Contributions:

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Title:
Glycosphingolipids and phospholipids as novel danger signals for activation of the NLRP3 inflammasome in prodromal Parkinson’s disease
Agreement Number:
967243
Agreement Value:
$25,000.00
Agreement Date:
Mar 11, 2021 - Sep 30, 2022
Description:
The objective of this collaboration is to test how systemic disruption of sphingolipid and phospholipid metabolism converges on systemic and nervous system-based immune responses to activate the NLRP3 inflammasome. We propose that this activation leads not only to cytokine production but, ultimately, ensures a vicious cycle of systemic aberrant immune responses by perpetuating pathological release of neurotoxic lipid mediators. Here we, will identify, using in vitro models and unbiased lipidomic approaches, the lipid mediators that initiate NRLP3 inflammasome activation, establish whether this induction is required to sustain systemic lipid dysregulation, and finally provide proof-of-principle that inhibiting the NLRP3 inflammasome will reverse the induction by pro-inflammatory lipid mediators.
Organization:
National Research Council Canada
Expected Results:

In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators.

Location:
Ottawa, Ontario, CA K1N 6N5
Reference Number:
172-2020-2021-Q4-967243
Agreement Type:
Grant
Report Type:
Grants and Contributions
Recipient Business Number:
119278877
Recipient Type:
Academia
Recipient's Legal Name:
University of Ottawa
Federal Riding Name:
Ottawa–Vanier
Federal Riding Number:
35078
Program:
Collaborative Science, Technology and Innovation Program – Ideation Fund
Program Purpose:

The Ideation Fund is intended to encourage, test and validate transformative research ideas generated by teams of NRC scientific personnel and external collaborators with complementary capabilities, acting as a demonstration phase for a continually-evolving suite of research and development (R&D) deliverables at the NRC. The fund supports exploratory research through two mechanisms: the New Beginnings Initiative and the Small Teams Initiative.

NAICS Code:
541710 - R&D in the physical, engineering and life sciences