Grants and Contributions:
Title:
Functional characterization of factors influencing natural killer (NK) cell activity against therapy-induced senescent solid tumor models
Agreement Number:
973726
Agreement Value:
$544,500.00
Agreement Date:
Jul 1, 2021 - Jun 30, 2025
Description:
Natural killer (NK) cells are lymphocytes that demonstrate cytotoxic activity towards cancer cells and are associated with good prognosis when present in solid tumors. In the past, NK cells have been used in adoptive cell transfer to treat various cancer with relative success. More recently, NK cells, modified with chimeric antigen receptor (CAR-NK cells), are being explored as potential off-the-shelf therapy and these have shown better efficacy and lower toxicity than equivalent CAR-T cells in pre-clinical animal models. However, mechanisms preventing the full cytotoxic anti-tumor activity of NK cells remain understudied. Hence, this project seeks to use whole-genome CRISPR screens in both NK and solid tumor cells to identify genes that, when inhibited, potentiate the cytotoxic activity of NK cells towards cancer cells. In turn, these genes will be therapeutically targeted or genetically modified in future iPSC-derived NK and CAR-NK cells to improve outcome in cancer patients.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Montreal, Quebec, CA H3T 1C5
Reference Number:
172-2021-2022-Q1-973726
Agreement Type:
Grant
Report Type:
Grants and Contributions
Recipient Business Number:
107491847
Recipient Type:
Academia
Additional Information:
This agreement has been amended 1 time(s). The end date of this agreement has been modified by 364 days.
Amendment Date
Sep 8, 2023
Recipient's Legal Name:
Centre hospitalier universitaire Sainte-Justine
Federal Riding Name:
Outremont
Federal Riding Number:
24054
Program:
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Purpose:
Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.
NAICS Code:
541710
Amendments: