Grants and Contributions:
Title:
Early detection of cognitive decline using epigenetic biomarkers in peripheral blood
Agreement Number:
991333
Agreement Value:
$114,400.00
Agreement Date:
Sep 1, 2022 - Aug 31, 2026
Description:
Aging is the predominant risk factor for developing Alzheimer's disease (AD) and other dementias. Recently, DNA methylation has been used to estimate the brain age and the brain age acceleration (defined as the difference between its biological and chronological ages) has been linked to increased risk of AD and other dementias. It remains an open question whether the brain’s accelerated aging can be inferred from DNA methylation obtained from easily accessible tissues such as peripheral blood. The main objective of this project is to identify peripheral blood epigenetic biomarkers for brain age, AD and other dementias and develop a predictive machine learning model for evaluating disease risk. Such a predictor would enable us to identify those people at greatest risk of developing the disease earlier, when disease modifying therapies are deemed most effective, reducing the need for long-term care and increasing quality of life.
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Montreal, Quebec, CA H3T 1E2
Reference Number:
172-2021-2022-Q1-991333
Agreement Type:
Grant
Report Type:
Grants and Contributions
Recipient Business Number:
130104466
Recipient Type:
Academia
Additional Information:
This agreement has been amended 1 time(s). The end date of this agreement has been modified by 365 days.
Amendment Date
Sep 3, 2025
Recipient's Legal Name:
Centre intégré universitaire de santé et de services sociaux du Centre-Ouest-de-l'Île-de-Montréal
Federal Riding Name:
Mount Royal
Federal Riding Number:
24048
Program:
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Purpose:
Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.
NAICS Code:
541710
Amendments: