Grants and Contributions:

Development of an AAV library

988603

$165,000.00

Mar 29, 2022 - Mar 31, 2024

There are about 7,000 different hereditary diseases each due to the mutation of a gene. These genes are expressed in different cells. The treatment of these diseases requires the delivery of a normal gene or of gene modifying agents to the appropriate cells, i.e. those involved in the disease. Adeno-associated virus (AAV) is currently the most commonly used virus for the delivery of these components. However, delivery by AAVs is not sufficiently effective and specific for effective treatment of many hereditary diseases. Thus, the objective of this project is to modify the AAVs to produce some variants, which are more specific and more effective. The team’s approach is to modify the proteins, which are at the surface of the AAVs to change their binding to the proteins, sugar and lipids at the surface of target cells. This project will generate new AAV variants able to infect more effectively various types of cells to improve the efficacy of gene therapy

National Research Council Canada

In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.

Laval, Quebec, CA G1V 0A6

172-2021-2022-Q4-988603

Grant

Grants and Contributions

119278950

Academia

Université Laval

Louis-Hébert

24044

Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives

Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.

541710