Grants and Contributions:

Title:
Discovery of Single-Cell Omics Biomarkers in Alveolar Macrophages for Immunotherapy of Chronic Obstructive Pulmonary Disease
Agreement Number:
994662
Agreement Value:
$385,000.00
Agreement Date:
Nov 1, 2022 - Oct 31, 2025
Description:
Chronic obstructive pulmonary disease (COPD) is a common respiratory disorder that affects 384 million people worldwide and is responsible for over 3 million deaths/year, making it the third leading cause of mortality. COPD is also the top 1 reason for hospitalization in Canada. Alveolar Macrophages (AMs) are the most abundant immune cells in the human airways. Although AM is well known for its critical role in fighting pathogens and maintaining lung homeostasis, it is unclear how these cells change in COPD states. Precisely deconvolute the AM compositions and associating them to COPD clinical outcomes will provide a great opportunity to better understand COPD. The primary objective of this study is to develop digital technologies to discover AM biomarkers for novel COPD therapy by integrating both bulk and single cell omics data. This study will demonstrate the translational capabilities of single-cell ‘omics technologies and provide biomarker candidates for immunotherapy of COPD.
Organization:
National Research Council Canada
Expected Results:

In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.

Location:
Victoria, British Columbia, CA V8W 2Y2
Reference Number:
172-2022-2023-Q2-994662
Agreement Type:
Grant
Report Type:
Grants and Contributions
Recipient Business Number:
108162470
Recipient Type:
Academia
Recipient's Legal Name:
University of Victoria
Federal Riding Name:
Victoria
Federal Riding Number:
59041
Program:
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Purpose:

Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.

NAICS Code:
541710