Grants and Contributions:
Title:
A CAR-T Potency assay linking metabolism with CyTOF Profiling
Agreement Number:
1000406
Agreement Value:
$217,525.00
Agreement Date:
Jan 1, 2023 - Sep 30, 2025
Description:
Chimeric antigen receptor T cells (CAR-T) are produced from a patient’s own Tcells in order more actively engage the immune system in cancer treatment. The CAR-T production process is highly complex and assays are not currently available to accurately predict the potency of the CAR-T cell product. This project will develop and verify a panel of protein biomarkers that measure both T-cell activation and metabolic programming in order to assay CAR-T potency using cytometry time of flight mass spectrometry (CyTOF). We will analyse Tcells and CAR-T cells from banked samples and ongoing clinical trials being conducted in Canada. This data will be linked to benchmark our novel CyTOF potency assay versus current standard metabolic and functional assays of CAR- PAGE 4 T cell potency. The outcome will be a verified potency assay that can be used to predict efficacy of CAR-T treatment
Organization:
National Research Council Canada
Expected Results:
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Location:
Toronto, Ontario, CA M5G 2C4
Reference Number:
172-2022-2023-Q4-1000406
Agreement Type:
Grant
Report Type:
Grants and Contributions
Recipient Business Number:
119259505
Recipient Type:
Not-for-profit organization or charity
Additional Information:
This agreement has been amended 1 time(s). The end date of this agreement has been modified by 273 days.
Amendment Date
Dec 5, 2024
Recipient's Legal Name:
University Health Network
Federal Riding Name:
University--Rosedale
Federal Riding Number:
35112
Program:
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Purpose:
Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.
NAICS Code:
541710
Amendments: