Grants and Contributions:

Title:

Harnessing the benefits of continuous crystallization to precisely control particular size_x000D_ distribution of active pharmaceutical ingredients

Agreement Number:

EGP

Agreement Value:

$25,000.00

Agreement Date:

May 10, 2017 -

Organization:

Natural Sciences and Engineering Research Council of Canada

Location:

British Columbia, CA

Reference Number:

GC-2017-Q1-00376

Agreement Type:

Grant

Report Type:

Grants and Contributions

Additional Information:

Grant or Award spanning more than one fiscal year. (2017-2018 to 2018-2019)

Recipient's Legal Name:

Hein, Jason (The University of British Columbia)

Program:

Engage Grants for Universities

Program Purpose:

Control of crystallite particle size distribution is essential in the manufacturing of pharmaceutical dosagex000D
forms. In particular, obtaining a narrow size distribution is essential to enable new sustained release technologyx000D
developed by Eupraxia pharmaceuticals. The present workflow presents a significant barrier to scale up andx000D
manufacturing of a novel anti-inflammatory therapy. New techniques designed by the Hein lab, whichx000D
leverages automation and in situ monitoring technology, will help to identify optimal crystallization conditionsx000D
to achieve a narrow and controlled particle size distribution for the active pharmaceutical ingredient. Inx000D
addition, the Hein lab will investigate adapting the optimized crystallization process into a continuousx000D
crystallization workflow, making the final manufacturing stage robust and very efficient.