Grants and Contributions:

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Title:

Synthesis of TRIOZAN-Peptide Conjugates as Blood-Brain Transient Drug Nanovector

Agreement Number:

EGP

Agreement Value:

$25,000.00

Agreement Date:

Jul 12, 2017 -

Organization:

Natural Sciences and Engineering Research Council of Canada

Location:

Quebec, CA

Reference Number:

GC-2017-Q2-00045

Agreement Type:

Grant

Report Type:

Grants and Contributions

Additional Information:

Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019).

Recipient's Legal Name:

Dory, Yves (Université de Sherbrooke)

Program:

Engage Grants for Universities

Program Purpose:

In spite of considerable advancement in cancer chemotherapy, the survival rate in brain cancer patients isx000D
extremely limited mainly due to the blood-brain barrier (BBB) which prevents the transmission of drug fromx000D
blood circulation into the brain parenchyma. The present research proposal is based on the conjugation ofx000D
TRIOZANTM, as a nanomedicine delivery platform under proprietary of Ovensa Inc., with B1R agonist ligand.x000D
The permeability of B1R-functionalized TRIOZANTM will be evaluated via the measurement of its bindingx000D
affinity to the endothelial cell receptors. Developed technology will be transferred to Ovensa Inc. as a key stepx000D
in developing of blood-brain-transient drug delivery platform.